Journal article
Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria
WQ He, AR Shakri, R Bhardwaj, CT França, DI Stanisicid, J Healer, B Kiniboro, LJ Robinson, M Guillotte-Blisnick, C Huon, P Siba, A Cowman, CL King, WH Tham, CE Chitnis, I Mueller
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2019
Abstract
Background The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), including the AH, O, P and Sal1 alleles, the central region III-V (PvDBPIII-V), and P. vivax Erythrocyte Binding Protein region II (PvEBPII) and their associations with risk of clinical P. vivax malaria are not well understood. Methodology Total IgG and IgG subclasses 1, 2, and 3 that recognize four alleles of PvDBPII (AH, O, P, and Sal1), PvDBPIII-V and PvEBPII were measured in samples collected from a..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
W.Q.H. is supported by both Melbourne International Postgraduate Scholarship (MIPS) and Melbourne International Research Scholarship (MIRS), C.T.F is under the support of MIPS. W.H.T. is a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (208693/Z/17/Z). I.M. was supported by an NHMRC Research Fellowship (APP1043345). This work was supported by National Institutes of Health (AI063135, AI-46919, TW007872, 1 U19 AI089686-01, 1 U19 AI129392-01), the National Health & Medical Research Council (APP1102297 and 1092789), BIRAC, Department of Biotechnology, Govt. of India, Institut Pasteur intramural grant (PTR 490), the Victorian State Government Operational Infrastructure Support, and PATH Malaria Vaccine Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.